Researchers are testing the effectiveness of Metformin to help improve daily living for individuals with Fragile X syndrome.

The trial further assesses Metformin’s safety, as well as the benefits of the drug, which has been shown to improve the symptoms and difficulties individuals with FXS experience, including: delayed language/cognition, excessive eating, obesity, hypogonadism, and delayed puberty.

Participation

Who can participate?

Individuals aged 6–35 who have been diagnosed with FXS.

What will happen in the study?

Commit to a four-month study which includes three clinic visits, and five phone calls while taking Metformin orally. Complete various tasks, questionnaires, and examinations by a physician/research team, as well as have blood drawn, as well as urine and stool samples taken.

Will you/your child be paid to complete this survey?

Travel expenses will be reimbursed.

Study doctors and locations

Please fill out the form below to send your contact information to the study coordinators.

Dr. Francois Bolduc, Principal Investigator
University of Alberta/Stollery Children’s Hospital
Edmonton, Alberta, Canada

Clinical Research Coordinator: Call (780) 492-9461 or email

Dr. Sébastien Jacquemont, Principal Investigator
CHU Ste. Justine
Montreal, Quebec, Canada

Study Coordinators: Maryse Thibeault or Sophie Morin

Our Most Recent Opportunities
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FXS TECH Study

Researchers at Rush University Medical Center are working on technology to improve how to identify and track progress in children living with autism and Fragile X syndrome. The study is currently recruiting children ages 18 months to 5 years, and 12-18 years.

Study: Web Intervention for Parents of Youth with Genetic Syndromes (WINGS)

Researchers at the Autism Assessment, Research, Treatment & Services (AARTS) Center at Rush University Medical Center are currently conducting a fully-virtual research study that is testing two telehealth interventions that are designed to help parents of children with genetic syndromes and intellectual disabilities gain strategies to manage challenging behaviors.

Brain & Behavior Study

Researchers at Purdue University are conducting a natural history research study to learn about brain activity in females, ages18-60 years, living with the FMR1 premutation.