Individuals with the Fragile X premutation are at an increased risk for depression, other psychiatric conditions, and developing Fragile X tremor/ataxia syndrome (FXTAS). Our goal is to better understand the different mechanisms within the brain that contribute to the development of psychiatric conditions, including depression. Doing so will allow us to establish better prevention and intervention efforts within this population.
Q: Who can take part in this study?
We are currently recruiting females between 18-60 who carry the FMR1 premutation.
Q: What will participation involve?
Participation involves four types of data collection:
- Web-based questionnaires.
- In-person assessments that involve responding quickly to shapes and viewing emotional stimuli.
- Gathering a variety of biological measurements such as brain activity (EEG and/or MRI), heart rate activity, and a blood draw.
- Interviews about your feelings and experiences.
Q: How will this project help the Fragile X community?
We hope that our data will impact the broader community of individuals with the Fragile X premutation and depression by improving our understanding of brain mechanisms and treatment needs.
Q: Will I need to travel?
All assessments and tests for this study are done in person and at Purdue in West Lafayette, Indiana. Travel reimbursement may be available for folks who are commuting more than 45 minutes from the Purdue campus.
Q: How can I get more information?
This project is led by Dr. Dan Foti and Dr. Bridgette Tonnsen in the Department of Psychological Sciences at Purdue University. To learn more, please complete the form below and they will contact you.
This study is funded by Purdue University and the Indiana Clinical & Translational Sciences Institute. Photo courtesy of Matthew Thomas of Purdue University.
NOTE: This study is not currently recruiting individuals.
Our Most Recent Opportunities
Doctors at Rush University are researching cognition, balance, and walking patterns in people who carry a premutation in the Fragile X (FMR1) gene.
The University of South Carolina is conducting a research study focusing on the range of language, social, and cognitive features that may be associated with variations on the FMR1 gene. Women age 35-75 who are carriers of the Fragile X premutation may be eligible to participate.
An Alliant International University clinical psychology doctoral candidate is conducting a research study to learn about the cognitive profile of children with a full mutation of Fragile X. Males and transgender females between the age of 8 and 12 may be eligible to participate.
The MIND Group at the University of Minnesota is conducting a survey for parents of children with Fragile X syndrome to learn about how genetic and neurodevelopmental differences impact behavioral strengths and challenges. Parents of 3–17 year old children living with Fragile X are eligible to participate.
Purdue University is conducting a research study to learn about language and social communication development in Fragile X syndrome. Children ages 3–4 years (36–60 months) with the full mutation may be eligible to participate.