JUN 26, 2013 | Why is there so much variability among male and female Fragile X carriers? There are a number of factors involved. Because the Fragile X gene is X-linked, gender plays a big role in determining who might show symptoms. Male premutation carriers, because they have only one X chromosome, are much more commonly affected by FXTAS than are female carriers.
FEB 5, 2017 | Unlike many other genetic changes that are passed down in a straightforward way, inheritance of the FMR1 gene is very complicated. When a person first learns that they have a Fragile X intermediate allele, there is often a lot of confusion about its meaning, even among medical providers who may mistakenly say that the person is a Fragile X carrier.
DEC 8, 2014 | Understanding the distinction between the two can be particularly helpful when deciding upon the most appropriate medical, therapeutic, counseling, and education interventions, and will increase the potential for both short- and long-term benefits.
JUL 29, 2013 | Direct questions are typically the way we try to engage people in conversation. For children with FXS, we need to learn other strategies. It is critical to understand why it is so difficult for children with FXS to understand and respond to these questions, before we get to the how of getting answers.
DEC 18, 2014 | Females with FXS show a high frequency of avoidant behavior, mood disorders, attention deficits, and learning disabilities. They are significantly more withdrawn and depressed than their typical cohorts. This makes them most vulnerable to social anxiety and avoidance.