We are excited to share journal publications like this one resulting from FORWARD data. There are many more papers currently in development, and the future for Fragile X syndrome research is bright as more data is gathered.
Auditory processing abnormalities in Fragile X syndrome may contribute to difficulties with language development, pattern identification, and contextual updating.
Participants with FXS and controls underwent auditory event-related potentials (ERP) during presentation of an oddball paradigm. The group with FXS showed abnormal amplitudes and latencies to oddball stimuli relative to controls, with females more like controls. Increased gamma power was seen in both males and females with FXS. The FXS cohort showed a normal developmental trajectory for most measures and good test-retest reproducibility.
This data informs use of these ERP paradigms for target engagement, and potentially subject selection in clinical trials by providing key data on abnormal measures related to auditory processing in FXS, gender and age dependence of the abnormalities, and measure reproducibility.
Lauren Ethridge, Andrew Thaliath, Jeremy Kraff, Karan Nijhawan, Elizabeth Berry-Kravis; Development of Neural Response to Novel Sounds in Fragile X Syndrome: Potential Biomarkers. Am J Intellect Dev Disabil 1 November 2020; 125 (6): 449–464. doi: https://doi.org/10.1352/1944-7558-125.6.449