We are excited to share journal publications like this one resulting from FORWARD data. There are many more papers currently in development, and the future for Fragile X syndrome research is bright as more data is gathered.
This study looked at mosaicism in males with Fragile X syndrome. Most males with FXS make very little or no amount of a protein, called FMR1, that is important for brain development. This happens because the gene that makes this protein has been “turned off” in all of the cells in their body by a process called methylation. However, some males with FXS have what is called “methylation mosaicism” which means that some, though not all, of their cells have a gene that has not been turned off by methylation and can still make the FMR1 protein.
In this study, participants with methylation mosaicism tended to have less severe intellectual disability and better social and functional skills. More research needs to be done, but knowing more about how FXS differs in people with and without methylation mosaicism may eventually help guide expectations and treatment of individuals with FXS.
Meng, L., Kaufmann, W. E., Frye, R. E., Ong, K., Kaminski, J. W., Velinov, M., & Berry-Kravis, E. (2022). The association between mosaicism type and cognitive and behavioral functioning among males with fragile X syndrome. American Journal of Medical Genetics Part A, 188A: 858– 866. doi:10.1002/ajmg.a.62594