In our ongoing effort to advance scientific understanding and advancing treatment research in all Fragile X-associated conditions and disorders, we are sharing information on an available funding opportunity.
The Fiscal Year 2026 (FY26) Research Funding Opportunities from the Congressionally Directed Medical Research Programs (CDMRP), Peer Reviewed Medical Research Program (PRMRP), have been released. Learn more about the FY26 funding mechanisms.
Peer Reviewed Medical Research Program (PRMRP)
Since 2010, more than $21M has been awarded to Fragile X-associated conditions and disorders research through the PRMRP, following its inclusion as an eligible topic area within CDMRP. For FY26, Fragile X, including all FMR1-associated conditions and disorders, remains an eligible topic area, supported through a $370M appropriation within the PRMRP portfolio.
The PRMRP is part of CDMRP within the Department of War and supports innovative, Congressionally directed biomedical research addressing critical health needs.
The NFXF and Fragile X community have long engaged in advocacy efforts supporting sustained federal research investment. This includes nominating consumer reviewers to participate in PRMRP peer and programmatic review, ensuring lived experience informs funding decisions alongside scientific expertise. The NFXF has also contributed community perspectives to help identify research gaps and priority needs.
Webinar
The PRMRP Program Manager will be hosting an informational Webinar. Additional details will be shared as it becomes available.
PRMRP Funding Opportunities/Mechanisms for Fragile X-associated Conditions and Disorders Research:
- Clinical Trial Award: Supports the rapid implementation of clinical trials of novel interventions. The Pre-Application (Preproposal) deadline is July 23, 2026, 5:00 p.m. ET.
- Platform Clinical Translation Award: Supports the translational development and/or early-phase clinical trials for broadly applicable clinical technologies that will address urgent and complex needs related to two congressionally directed FY26 PRMRP topic areas. The Pre-Application (Preproposal) deadline is July 23, 2026, 5:00 p.m. ET.
- Discovery Award: Supports the exploration of a highly innovative new concept or untested theory. Pre-Application (Letter of Intent) deadline is July 16, 2026, 5:00 p.m. ET.
- Impact Award: Supports applied research, defined as use-inspired and practice-oriented science that brings together outcomes from basic research, and insights from the real-world environment, to foster clinical applicability. Pre-Application (Letter of Intent) deadline is July 23, 2026, 5:00 p.m. ET.
- Lifestyle and Applied Health Research Award: Supports clinical research and/or clinical trials using a combination of scientific disciplines including occupational science, psychology, psychometrics, biostatistics and epidemiology, surveillance, implementation science, and population health. Pre-Application (Letter of Intent) deadline is July 23, 2026, 5:00 p.m. ET.
- Research Advancement Award: Supports fundamental research studies that will make an important contribution towards research, patient care, and/or quality of life for a disease or condition related to one of the congressionally directed FY26 PRMRP topic areas and one of the FY26 PRMRP portfolio-specific strategic goals. Pre-Application (Letter of Intent) deadline is July 16, 2026, 5:00 p.m. ET.
- Technology/Therapeutic Development Award: Supports the translation of promising preclinical findings into products for clinical applications for prevention, detection, diagnosis, treatment, and/or quality of life. Pre-Application (Letter of Intent) deadline is July 23, 2026, 5:00 p.m. ET.
- Synopsis of FY26 PRMRP Award Mechanisms – provides a brief description and key elements of the award mechanism.
Partnering with the NFXF Throughout the Research Process
The NFXF can help! The PRMRP program appreciates partnerships between patient advocacy groups and researchers.
The NFXF Research Facilitation portfolio leverages our skills to create meaningful partnerships with all researchers, from initial concept through the dissemination of results. We support our research facilitation mission through the NFXF Research Readiness Program, our services menu, focused projects, and advocacy. We recommend all researchers engage in the program early for support from concept through the conclusion of the research project.
