Development of Neural Response to Novel Sounds in Fragile X Syndrome: Potential Biomarkers

We are excited to share journal publications like this one resulting from FORWARD data. There are many more papers currently in development, and the future for Fragile X syndrome research is bright as more data is gathered.

Auditory processing abnormalities in Fragile X syndrome may contribute to difficulties with language development, pattern identification, and contextual updating.

Participants with FXS and controls underwent auditory event-related potentials (ERP) during presentation of an oddball paradigm. The group with FXS showed abnormal amplitudes and latencies to oddball stimuli relative to controls, with females more like controls. Increased gamma power was seen in both males and females with FXS. The FXS cohort showed a normal developmental trajectory for most measures and good test-retest reproducibility.

This data informs use of these ERP paradigms for target engagement, and potentially subject selection in clinical trials by providing key data on abnormal measures related to auditory processing in FXS, gender and age dependence of the abnormalities, and measure reproducibility.

About the FORWARD-MARCH Registry & Database

Since 2012, the CDC has funded four FORWARD Fragile X studies to expand understanding of Fragile X syndrome. The NFXF has been coordinating study efforts since the beginning and has been vital in ensuring its success.

FORWARD-MARCH is the next step and will collect more detailed information from participants to better understand FXS and improve the lives of children and adolescents with FXS and the lives of their families.

Below are more journal publications resulting from FORWARD data. 

more from forward