Study: FX-LEARN – Language Learning in Children with FXS

/, Research/Study: FX-LEARN – Language Learning in Children with FXS

Study: FX-LEARN – Language Learning in Children with FXS

Are you interested in a language intervention that may help your child with Fragile X Syndrome communicate better?

Dr. Elizabeth Berry-Kravis at Rush University is the Protocol Principal Investigator and is leading a national study, NN107 FX-LEARN. There are two purposes to the study. First, to find out if the drug AFQ056, made by the pharmaceutical company Novartis, is safe and has beneficial effects on learning in children who have Fragile X syndrome (FXS).  Second, to find out if a structured language intervention can help children with Fragile X syndrome communicate better.

The trial will be a multi-center, phase II randomized, double-blind placebo-controlled parallel-group flexible-dose forced-titration study that will use a novel design to address the impact of AFQ056 on language learning in 3- to 6-year-old children with FXS. Subjects will be in the study a total of 21 months (Screening and 12 months placebo-controlled treatment, 8 months open-label extension, 1 month follow up after final assessment visit). The study is conducted by the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT). The National Institute of Neurological Disorders and Stroke (NINDS), a division of the National Institutes of Health (NIH), is supporting this trial.

Who can participate?

Children ages 3-6:

  • With Fragile X Syndrome.
  • Who use intentional acts of communication (including words, gestures, and augmentative communication devices).

What does the study involve?

  • 15 study visits over 21 months.
  • Behavioral and language assessments, medical history, a physical exam, parent questionnaires, and blood and urine sampling.
  • Weekly video conferencing sessions in your home to learn strategies to help your child with language.
  • Child will be randomized to either AFQ056 or placebo.

What else can I expect?

  • Families receive instruction and feedback from expert speech and language pathologists.
  • Travel reimbursement is available.

How can I learn more before applying?

Where can I participate?

  • The following clinical sites are currently enrolling participants. Use the contact form on this page to be connected with the coordinator, Katie Friedmann, RN, who will work to get you enrolled, if eligible, at the most convenient and available site.
Boston Children’s Hospital University of Cincinnati Medical Center Children’s Hospital of Philadelphia
University of Colorado – Denver Children’s National Medical Center (DC) University of Pittsburgh
Columbia University Medical Center (NY) University of Texas Southwestern Medical Center Emory University (GA)
Vanderbilt University (TN) Nationwide Children’s Hospital (OH) Washington University in Saint Louis
Rush University (IL) Yale University (CT) University of California at Davis

NFXF FX-LEARN Q&A Webinar with Dr. Berry-Kravis

If you’d like to learn more or apply for this opportunity, please fill out the form to send your contact information to the study coordinators.

View More Opportunites

Visual Perception Study

Jun 12, 2019|

Purdue University: Brain and Behavior Study

Jun 11, 2019|

Reproductive Decision Making Study

Jun 11, 2019|

Study on Language Development in Young Adults with Fragile X Syndrome

May 23, 2019|

Canada: Metformin Clinical Trial

May 21, 2019|

Adults with FXS Needed for AZD7325 Trial

Mar 29, 2019|

Study: FX-LEARN – Language Learning in Children with FXS

Mar 27, 2019|

Research Study on Language and Brain Imaging

Mar 11, 2019|

Why Do Some People Have Seizures and Others Do Not?

Mar 5, 2019|

By | 2019-04-15T10:50:38+00:00 Mar 27, 2019|Opportunities for families, Research|Comments Off on Study: FX-LEARN – Language Learning in Children with FXS