At a Glance
- Study Type: Clinical Trial
- Condition: Fragile X Syndrome
- Age: 6–25
- Sex: All
- Participant: Has FXS plus parent or caregiver
- Location: MIND Institute, Sacramento, CA
- Travel Considerations: At research facility, travel reimbursement available
We are actively recruiting individuals diagnosed with FXS ages 6–25 to participate!
We have preliminary evidence that metformin, a common type 2 diabetes medication, is beneficial for language, cognition, and behavior in both children and adults with Fragile X Syndrome. It is our hope that this study will lead to a better understanding of the benefits of treatment with metformin for individuals with FXS and inform future treatment and interventions.
Q: Who can participate?
- Individuals 6–25 years of age diagnosed with FXS.
- A reliable parent or caregiver who can report the side effects and communicate effectively with the research team for 4 months.
- Study excludes individuals who have taken metformin in the past year.
- Study excludes individuals with other serious illness or medical problem that would interfere with the study.
Q: What does the study involve?
- Three visits to the MIND Institute (located in Sacramento, California).
- Travel reimbursement available per research facility visit.
- Subjects will participate in cognitive, language, sensory, and social assessments administered by the MIND Institute team.
- Caregivers/parents will complete behavioral questionnaires.
- Medical appointments with Dr. Randi Hagerman and her team.
- Randomized assignment to either metformin or placebo capsules, with routine follow-up by research team.
- Three blood draws.
Q: What else is expected?
- Subjects may experience an improvement in physical health, behavioral symptoms, and/or cognitive abilities as a result of treatment with metformin.
- Families can receive feedback on the subject’s performance on the standardized tests that are part of the study.
- Results from this study will have the potential to positively influence the trajectory of development in FXS.
About the MIND Institute
The UC Davis MIND Institute is a collaborative international research center, committee to the awareness, understanding, prevention, and care of neurodevelopmental disorders. Visit mindinstitute.ucdavis.edu for more information.
All studies take place at: MIND Institute, 2825 50th Street, Sacramento, California, 95817
“We can’t have real targeted treatments for Fragile X syndrome that will improve lives more than current supportive treatments without doing science that’s totally new and going where no clinician, researcher, or the FDA has gone before.”
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