The Impact of an ASD Co-Diagnosis on Behaviors in FXS
There are many different types of behaviors associated with ASD, regardless of ASD status and age, particularly attention issues and anxiety. In the first large scale study looking at autism in FXS, and using FORWARD and Fragile X clinic data, the charts below shows behaviors associated with FXS+ASD and FXS only, by age group (ages 3–11 and 12–21), in subjects enrolled in theFORWARD Database from September 7, 2012, through August 31, 2014.
In general, the behavioral profiles were similar in both age groups. Regardless of their relative frequency, however, hyperactivity, hypersensitivity/overreactivity, perseverative/obsessive compulsive behavior, and irritability/aggressive behavior was much higher among those with FXS+ASD versus those with FXS only. The difference between FXS+ASD and FXS was less striking for anxiety, with only the older (ages 12–21) FXS+ASD group showing significantly higher anxiety than FXS only (98% vs. 87%). As a whole, mood swings/depression problems were less common (∼18%), with no significant difference between FXS+ASD and FXS only.